AZPFKFB326是一种有效的选择性代谢激酶PFKFB3抑制剂，IC50为23nM。AZPFKFB326抑制PFKFB1和PFKFB2，IC50分别为2.06和0.384μM。
CAS：1704740-52-2
分子式：C24H26N4O2
分子量：402.49
纯度：98%
存储：Store at -20°C

Background:

AZ PFKFB3 26 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 23 nM. AZ PFKFB3 26 inhibits PFKFB1 and PFKFB2 with IC50s of 2.06 and 0.384 μM, respectively[1]. IC50: 23 nM (PFKFB3), 2.06 μM (PFKFB1), 0.384 μM (PFKFB2)[1]

[1]. Boyd S, et al. Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3. J Med Chem. 2015 Apr 23;58(8):3611-25.