您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > 5-HT6/7 antagonist 1
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
5-HT6/7 antagonist 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5-HT6/7 antagonist 1图片
CAS NO:131999-28-5
规格:98%
分子量:393.41
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
5-HT6/7 antagonist 1是多功能的 5-HT6/7/2A 和 D2 受体拮抗剂,但不与M1受体和hERG通道相互作用。
CAS:131999-28-5
分子式:C22H20FN3O3
分子量:393.41
纯度:98%
存储:Store at -20°C

Background:

5-HT6/7 antagonist 1 is a multifunctional ligand that antagonizes 5-HT6/7/2A and D2 receptors, without interacting with M1 receptors and hERG channels. 5-HT6/7/2A, D2[1]


Targeting 5-HT6 and/ or 5-HT7 receptors with antagonist drugs could constitute a promising strategy for treating symptoms of BPSD while avoiding some of the side effects of current antipsychotic drugs. Nevertheless, due to the complex pathology of dementia and accompanying behavioral and psychological symptoms, it seems unlikely that focusing on a single therapeutic target would be sufficient to provide adequate clinical benefit, and it is likely that successful development of novel anti-BPSD agents should involve a "designed" multifactorial approach[1].



[1]. Ko?aczkowski M, et al. Novel arylsulfonamide derivatives with 5-HT?/5-HT? receptor antagonism targeting behavioral and psychological symptoms of dementia. J Med Chem. 2014 Jun 12;57(11):4543-57.