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U-51605
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
U-51605图片
CAS NO:64192-56-9
规格:98%
分子量:332.5
包装与价格:
包装价格(元)
5mg电议
100ug电议
500ug电议
1mg电议

产品介绍
U-51605 is a stable analog of the endoperoxide prostaglandin H2 (PGH2).
CAS:64192-56-9
分子式:C20H32N2O2
分子量:332.5
纯度:98%
存储:Store at -20°C

Background:

U-51605 is a stable analog of the endoperoxide prostaglandin H2 (PGH2). It is an inhibitor of both prostacyclin (PGI) and thromboxane (TX) synthases with more selectivity towards PGI synthase. U-51605 is also a partial agonist at TP receptors. In human foreskin fibroblasts, U-51605 inhibits PGI synthase at a concentration of 2.8 µM, whereas, human platelet TX synthase is inhibited at a concentration of 5.6 µM. At concentrations up to 1 µM, U-51605 reduced the release of prostacyclin in SHR aorta elicited by the calcium ionophore A-23187 with no effect on TXA2 production and yet significantly increased PGE2 and PGF2α release.