YF-2是一种高度选择性、可透过血脑屏障的组蛋白乙酰转移酶(histoneacetyltransferase)激动剂，能够在海马区乙酰化H3，对CBP，PCAF和GCN5的EC50值分别为2.75μM，29.04μM和49.31μM，对HDAC无作用。具有抗肿瘤和抗阿尔滋海默症的活性。
CAS：1311423-89-8
分子式：C20H22ClF3N2O3
分子量：430.85
纯度：98%
存储：Store at -20°C

Background:

YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer’s disease[1].

YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1].

YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice[1].

[1]. FENG, Yen, et al. HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF. WO 2011072243A1.