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inS3-54A18
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
inS3-54A18图片
CAS NO:328998-53-4
规格:98%
分子量:373.83
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
inS3-54A18是有一种有效的STAT3抑制剂,具有抗癌作用。
CAS:328998-53-4
分子式:C23H16ClNO2
分子量:373.83
纯度:98%
存储:Store at -20°C

Background:

inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.


inS3-54A18 (5 μM) reduces wound healing to 64% and 76% for A549 and MDA-MB-231 cells, respectively. inS3-54A18 at 10 μM further reduces the healing to 47% and 39%, respectively. inS3-54A18 inhibits the expression of STAT3 downstream target genes and the binding of STAT3 to its endogenous target sequences. inS3-54A18 does not affect the constitutive or IL-6-induced STAT3 activation (Tyr705 phosphorylation) but represses STAT3 target gene (survivin) expression[1].


inS3-54A18 (200 mg/kg, p.o.) inhibits tumor growth, metastasis and expression of STAT3 target genes in a mouse xenograft model of A549 cells[1].


[1]. Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92