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E3 ligase Ligand-Linker Conjugates 12
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
E3 ligase Ligand-Linker Conjugates 12图片
CAS NO:1797406-80-4
规格:98%
分子量:645.77
包装与价格:
包装价格(元)
100mg电议
500mg电议
1g电议
2g电议

产品介绍
E3ligaseLigand-LinkerConjugates12是用于PROTAC技术的化合物,其结合了E3连接酶配体和连接桥。
CAS:1797406-80-4
分子式:C30H43N7O7S
分子量:645.77
纯度:98%
存储:Store at -20°C

Background:

E3 ligase Ligand-Linker Conjugates 12 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.


E3 ligase Ligand-Linker Conjugates 12 is extracted from patent WO/2016/146985A1, figure 11. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker[1][2].



[1]. WO/2016/146985A1 [2]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.