PD90780是一种非肽类的神经生长因子NGF拮抗剂，与NGF上的P75受体结合，抑制NGF与神经营养素受体p75NTR(NGF-p75NTR)的相互作用，在PC12细胞和PC12nnr5细胞中，抑制NGF-p75NTR的IC50值分别为23.1μM和1.8μM。
CAS：77422-99-2
分子式：C19H14N4O4
分子量：362.34
纯度：98%
存储：Store at -20°C

Background:

PD 90780 is a non peptide antagonist of nerve growth factor (NGF) binding to the P75 NGF receptor, inhibits NGF-p75 NTR interaction with IC50s values of 23.1 µM and 1.8 µM in PC12 cells and PC12 nnr5 cells, respectively [1] . IC50: 23.1 µM (NGF, PC12 cells), 1.8 µM (NGF, PC12 nnr5 cells)

[1]. Colquhoun A , et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J Pharmacol Exp Ther. 2004 Aug;310(2):505-11.