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3-Deoxysappanchalcone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3-Deoxysappanchalcone图片
CAS NO:112408-67-0
规格:98%
分子量:270.28
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
3-Deoxysappanchalcone 是一种从豆科植物 Caesalpinia sappan L. 中分离得到的天然查尔酮化合物,具有抗过敏、抗病毒、抗炎和抗氧化活性。3-Deoxysappanchalcone 通过激活小鼠巨噬细胞中 AKT/mTOR 通路诱导血红素加氧酶 -1 (HO-1) 的表达,发挥抗炎作用。3-Deoxysappanchalcone 具有抗流感病毒活性 (H3N2, IC50 = 1.06 μM)。
CAS:112408-67-0
分子式:C16H14O4
分子量:270.28
纯度:98%
存储:Store at -20°C

Background:

3-Deoxysappanchalcone is a naturally-occurring chalcone compound isolated from Caesalpinia sappan L. (Leguminosae), which possesses anti-allergic, antiviral, anti-inflammatory and antioxidant activities. 3-Deoxysappanchalcone exerts anti-inflammatory activity via induce heme oxygenase-1 (HO-1) expression by activating the AKT/mTOR pathway in murine macrophages. 3-Deoxysappanchalcone also exhibits anti-influenza virus activity (H3N2, IC50 = 1.06 μM)[1][2]. IC50: 1.06 μM (H3N2)[2]




[1]. Kim JH, et al. The anti-inflammatory effect of 3-deoxysappanchalcone is mediated by inducing heme oxygenase-1 via activating the AKT/mTOR pathway in murine macrophages. Int Immunopharmacol. 2014 Oct;22(2):420-6. [2]. Liu AL, et al. In vitro anti-influenza viral activities of constituents from Caesalpinia sappan. Planta Med. 2009 Mar;75(4):337-9.