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11-trans Leukotriene C4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
11-trans Leukotriene C4图片
CAS NO:74841-69-3
规格:98%
分子量:625.8
包装与价格:
包装价格(元)
25ug电议
50ug电议
100ug电议

产品介绍
11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4.
CAS:74841-69-3
分子式:C30H47N3O9S
分子量:625.8
纯度:98%
存储:Store at -20°C

Background:

11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum as a cysteinyl leukotriene receptor preparation, the pKis for LTC4 and 11-trans LTC4 were determined to be 6.42 and 6.58, respectively.