COX/5-LO-IN-1是cylooxygenase和5-lipoxygenase的抑制剂，用于炎症性和过敏性疾病的研究。
CAS：154355-75-6
分子式：C16H15FN2O2S
分子量：318.37
纯度：98%
存储：Store at -20°C

Background:

COX/5-LO-IN-1 is an inhibitor of cylooxygenase and 5-lipoxygenase, used for the research of inflammatory and allergic disease states.

COX/5-LO-IN-1 reduces the biosynthesis of leukotrienes B4, C4, D4, and E4 and cyclooxygenase products such as prostaglandins and thromboxane and are useful in the treatment of inflammatory and allergic disease states[1]. COX/5-LO-IN-1 shows inhibitory activities against 5-lipoxygenase, with IC50 of 0.2 μM in human whole blood[2].

[1]. Lipoxygenase and cyclooxygenase inhibiting compounds. US 5516789 A [2]. Brooks CD, et al. (R)-(+)-N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor. J Med Chem. 1995 Nov 24;38(24):4768-75.