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Metyrapone Tartrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:908-35-0
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

Metyrapone Tartrate is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME. References: Weiler U, Finsler S, Claus R. Influence of cortisol, gonadal steroids and an energy deficit on biochemical indicators of bone turnover in Swine. J Vet Med A Physiol Pathol Clin Med. 2003 Mar;50(2):79-87. PubMed PMID: 12667198. 2: Dickstein G, Spindel A, Shechner C, Adawi F, Gutman H. Spontaneous remission in Cushing's disease. Arch Intern Med. 1991 Jan;151(1):185-9. Review. PubMed PMID: 1985595. 3: Mito T, Shiono T, Kimura R, Tamai M. The effect of oral metyrapone on aqueous humor dynamics in normal human eyes. Acta Ophthalmol (Copenh). 1990 Oct;68(5):582-6. PubMed PMID: 2275356. 4: Galinsky RE, Corcoran GB. Suppression of acetaminophen conjugation and of conjugate elimination in the rat by metyrapone, a classical P-450 inhibitor. Drug Metab Dispos. 1988 May-Jun;16(3):348-54. PubMed PMID: 2900724. 5: Levi L, Schwartz B. Decrease of ocular pressure with oral metyrapone. A double-masked crossover trial. Arch Ophthalmol. 1987 Jun;105(6):777-81. PubMed PMID: 3034221. 6: Lye SJ, Challis JR. In vivo adrenocorticotropin (1-24)-induced accumulation of cyclic adenosine monophosphate by ovine fetal adrenal cells is inhibited by concomitant infusion of metopirone. Endocrinology. 1984 Oct;115(4):1584-7. PubMed PMID: 6207013. 7: Whipple CA, Grodzicki RL, Hourihan J, Salhanick HA. Effects of cholesterol side chain cleavage inhibitors on 11 beta-hydroxylation: linkage of mitochondrial oxygenase systems. Steroids. 1981 Jun;37(6):673-9. PubMed PMID: 6974914. 8: Nelson EB, Montes M, Goldstein M. Effectiveness of methyrapone in the treatment of acetaminophen toxicity in mice. Toxicology. 1980;17(1):73-81. PubMed PMID: 7434370. 9: Evans DM, Fox JA. Influence of Metyrapone on Development of Heterodera glycines. J Nematol. 1978 Jul;10(3):211-6. PubMed PMID: 19305843; PubMed Central PMCID: PMC2617897. 10: Patt JA Jr, Eberhart RJ. Effects of metyrapone and ACTH on intestinal absorption of immunoreactive bovine IgG in cesarean-derived pigs. Am J Vet Res. 1976 Dec;37(12):1409-13. PubMed PMID: 187090. 1 Krupin T, Mandell AI, Podos SM, Becker B. Topical corticosteroid therapy and pituitary-adrenal function. Arch Ophthalmol. 1976 Jun;94(6):919-20. PubMed PMID: 938282. 12: Carson TE, Daane TA, Weinstein RL. Long-term intramuscular administration of triamcinolone acetonide. Effect on the hypothalamic-pituitary-adrenal axis. Arch Dermatol. 1975 Dec;111(12):1585-7. PubMed PMID: 1200663. 13: Bacon GE, Larson RM, Spencer ML, Kelch RP. Intravenous metyrapone testing. Evaluation of growth hormone and adrenocorticotrophic hormone in children. Am J Dis Child. 1975 Sep;129(9):1042-4. PubMed PMID: 1190177. 14: Meikle AW, Jubiz W, West CD, Tyler FH. A simple fluorometric method for assay of plasma metyrapone. J Lab Clin Med. 1969 Sep;74(3):515-20. PubMed PMID: 5806980. 15: LEFER AM, SUTFIN DC. CARDIOVASCULAR EFFECTS OF CATECHOLAMINES IN EXPERIMENTAL ADRENAL INSUFFICIENCY. Am J Physiol. 1964 May;206:1151-5. PubMed PMID: 14208957.

纯度:≥98%

CAS:908-35-0