您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Senazodan
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Senazodan
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Senazodan图片
CAS NO:98326-32-0
规格:98%
分子量:266.3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
Senazodan是一种Ca2+感光剂,同时可抑制PDEIII的活性。
CAS:98326-32-0
分子式:C15H14N4O
分子量:266.3
纯度:98%
存储:Store at -20°C

Background:

Senazodan is a Ca2+ sensitiser, and also shows inhibition effect on PDE III.


Senazodan seems to affect directly the actin-myosin crossbridge kinetics, and increase myosin ATPase activity[1]. Senazodan produces a concentration-dependent increase in tension development. Senazodan enhance Ca2+ binding to myofilaments and to purified cardiac troponin C. Senazodan also enhances contractility in guinea-pig papillary muscles by inhibiting PDE III[2].



[1]. Lehtonen LA, et al. Pharmacokinetics and pharmacodynamics of intravenous inotropic agents. Clin Pharmacokinet. 2004;43(3):187-203. [2]. Erhardt L. An emerging role for calcium sensitisation in the treatment of heart failure. Expert Opin Investig Drugs. 2005 Jun;14(6):659-70.