Extracted?from?whole herb and Achene of Silybum marianum L.Gaertn.;Store?the?product?in?sealed,?cool?and?dry?condition
CAS：29782-68-1
分子式：C25H22O10
分子量：482.44
纯度：98%
存储：Store at -20°C

Background:

Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 17.38?μM. Silydianin has inhibitory effect on the in vitro production and release of oxidative products[1][2][3].

参考文献:
[1]. Vostálová J, et al. Skin Protective Activity of Silymarin and its Flavonolignans. Molecules. 2019 Mar 14;24(6).
[2]. Qin N, et al. Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1283-1291.
[3]. Zielińska-Przyjemska M, et al. An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species. Phytother Res. 2006 Feb;20(2):115-9.