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Ceftriaxone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ceftriaxone图片
CAS NO:73384-59-5
规格:98%
分子量:554.58
包装与价格:
包装价格(元)
100mg电议
500mg电议

产品介绍
Ceftriaxone是抗生素,能结合PBPs。
CAS:73384-59-5
分子式:C18H18N8O7S3
分子量:554.58
纯度:98%
存储:Store at -20°C

Background:

Ceftriaxone is an antibiotic useful for the treatment of a number of bacterial infections.Target: AntibacterialCeftriaxone inhibits bacterial cell wall synthesis by means of binding to the penicillin-binding proteins (PBPs). Inhibition of PBPs would in turn inhibit the transpeptidation step in peptidoglycan synthesis which is required for bacterial cell walls. Like other cephalosporins, ceftriaxone is bacteriocidal and exhibits time-dependent killing. Ceftriaxone, one of the beta-lactam antibiotics, is a stimulator of EAAT2 expression with neuroprotective effects in both in vitro and in vivo models based in part on its ability to inhibit neuronal cell death by glutamate excitotoxicity. Based on this consideration and its lack of toxicity, ceftriaxone has potential to manipulate glutamate transmission and ameliorate neurotoxicity [1].




[1]. Lee, S.G., et al., Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. J Biol Chem, 2008. 283(19): p. 13116-23.