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Gossypol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gossypol图片
CAS NO:303-45-7
规格:98%
分子量:518.55
包装与价格:
包装价格(元)
50mg电议
100mg电议
200mg电议

产品介绍
PAF inhibitor;anti-fertility and anti-cancer
CAS:303-45-7
分子式:C30H30O8
分子量:518.55
纯度:98%
存储:Store at -20°C

Background:

Gossypol is a natural phenol compound derived from cotton stems, leaves, seeds, and flower buds.Gossypol has a 518.55 Dalton molecular weight and a yellow pigment. The most common toxic effectof Gossypolis the impairment of male and female reproduction. Another important toxic effect is its interference with immune function, reducing an animal’s resistance to infections and impairing the efficiency of vaccines[1].


In vitro: In bovine granulosa cells, treatment with gossypol dose-dependently decreased hCG-induced cAMP formation. Gossypol (12.5 μg/ml) inhibited basal cAMP level and progesterone secretion(2). Gossypol (50 and 100 μg/ml) decreased the percentage of sperm that completed the swim-up procedure. When cultured with5 or 10 μg/ml gossypol, development of cleaved embryos was reduced(3). In the lymphocytes isolated from lymph nodes of BALB/c mice, gossypol significantly inhibited the proliferation of mouse lymphocytes stimulated with phorbol ester plus ionomycin in a dose-dependent manner. Gossypol significantly suppressed the lymphoblastic transformation of both T and B lymphocyte subsets. Moreover, gossypol could induce apoptosis of lymphocytes in a time- and dose-dependent manner (4).


In vivo: In male Sprague-Dawley rats, gossypol (25 mg/kg, i.p.) caused marked changes in the activity of the hepatic and serum γ-glutamyltransferase (GGT) and microsomal monooxygenases (5). Rats that received lower gossypol doses (15 mg/kg/day for four weeks or 30 mg/kg/day for two weeks) showed morphological changes in the liver(6).


参考文献:
[1].  Gadelha I C N, Fonseca N B S, Oloris S C S, et al. Gossypol toxicity from cottonseed products[J]. The Scientific World Journal, 2014, 2014.
[2].  Lin Y C, Coskun S, Sanbuissho A. Effects of gossypol on in vitro bovine oocyte maturation and steroidogenesis in bovine granulosa cells[J]. Theriogenology, 1994, 41(8): 1601-1611.
[3].  Brocas C, Rivera R M, Paula-Lopes F F, et al. Deleterious actions of gossypol on bovine spermatozoa, oocytes, and embryos[J]. Biology of reproduction, 1997, 57(4): 901-907.
[4].  Xu W, Xu L, Lu H, et al. The immunosuppressive effect of gossypol in mice is mediated by inhibition of lymphocyte proliferation and by induction of cell apoptosis[J]. ActaPharmacologicaSinica, 2009, 30(5): 597-604.
[5].  Deoras D P, Young-Curtis P, Dalvi R R, et al. Effect of gossypol on hepatic and serum γ-glutamyltransferase activity in rats[J]. Veterinary research communications, 1997, 21(5): 317-323.
[6].  Ying W, Hai-Peng L. Hepatotoxicity of gossypol in rats[J]. Journal of ethnopharmacology, 1987, 20(1): 53-64.