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5-HT1A modulator 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5-HT1A modulator 1图片
CAS NO:142477-34-7
规格:98%
分子量:383.51
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
5-HT1Amodulator1对5HT1A,肾上腺素能α1和多巴胺D2受体具有非常高的亲和力,IC50分别为2±0.3nM,10±3nM和40±9nM。
CAS:142477-34-7
分子式:C21H25N3O2S
分子量:383.51
纯度:98%
存储:Store at -20°C

Background:

5-HT1A modulator 1 displays very high affinities for the 5HT1A, adrenergic α1 and dopamine D2 receptor with IC50s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively.


5-HT1A modulator 1 (Compound 24) also displays affinities for the 5HT1B, 5-HT2A and 5-HT2C receptor with IC50s of 300±55 nM, 500±75 nM, and 4000±440 nM, respectively[1].


5-HT1A modulator 1 (Compound 24) shows clear antagonist action at 5HT2A receptor subtype in mice. The antagonism is nearly complete at the dose of 1 mg/kg ip for 5-HT1A modulator 1 (94% of antagonism, p<0.01). 5-HT1A modulator 1 completely blocks the stereotypies and the climbing at the dose of 1 mg/kg ip (100% of antagonism). 5-HT1A modulator 1 is also tested in rats, using the same paradigm. After oral administration, 5-HT1A modulator 1 significantly (p<0.05) reduces the hyperactivity by 50% at the doses of 2 and 4 mg/kg po, respectively 63% and 58% of antagonism for 5-HT1A modulator 1; the antagonism is complete (103% and 108%) at the respective doses of 8 and 16 mg/kg po for 5-HT1A modulator 1 (p<0.01)[1].


[1]. Taverne T, et al. Novel benzothiazolin-2-one and benzoxazin-3-one arylpiperazine derivatives with mixed 5HT1A/D2 affinity as potential atypical antipsychotics. J Med Chem. 1998 Jun 4;41(12):2010-8.