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DuP 105
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DuP 105图片
CAS NO:96800-41-8
规格:98%
分子量:296.34
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
DuP105是一种可口服的恶唑烷酮类化合物,能够抗葛兰素阳性菌。
CAS:96800-41-8
分子式:C13H16N2O4S
分子量:296.34
纯度:98%
存储:Store at -20°C

Background:

DuP 105 is an orally active oxazolidinone, a new class of synthetic antimicrobial agent with activity against gram-positive bacteria.


DuP 105 shows inhibitory activities against staphylococcal isolates and B. fragilis isolates with MIC90s of 4 to 16 μg/mL and 16 μg/mL[1]. DuP 105 MICs for 50% of the 216 gram-positive isolates tested (MIC50s) range from 4.0 to 16 μg/mL[2].


DuP 105 administered by either the oral or the parenteral route is protective against staphylococcal and streptococcal infections in mice with the 50% effective doses of 9 to 23 mg/kg[1].


[1]. Slee AM, et al. Oxazolidinones, a new class of synthetic antibacterial agents: in vitro and in vivo activities of DuP 105 and DuP 721. Antimicrob Agents Chemother. 1987 Nov;31(11):1791-7. [2]. Barry AL, et al. In vitro evaluation of DuP 105 and DuP 721, two new oxazolidinone antimicrobial agents. Antimicrob Agents Chemother. 1988 Jan;32(1):150-2.