Duocarmycin 因特有的弯曲吲哚结构和螺环丙基环己二烯酮亲电试剂，而具有抗癌活性。 Duocarmycin 是一种 DNA 小沟结合烷化剂，并被探索做为药物-抗体结合物 (ADCs)。
CAS：1116745-06-2
分子式：C26H26ClN3O3
分子量：463.96
纯度：98%
存储：Store at -20°C

Background:

Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity. Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug-antibody conjugates (ADCs) [1].

[1]. Koch MF, et al. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13550-4.