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GSK3 Inhibitor XV
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK3 Inhibitor XV图片
CAS NO:936112-69-5
包装:1mg
规格:98%
市场价:4422元
分子量:633.4

产品介绍
GSK3 inhibitor XV is a racemic mixture of (R)-GSK3 inhibitor XV and (S)-GSK3 inhibitor XV.
CAS:936112-69-5
分子式:C25H14BrN3O6Ru
分子量:633.4
纯度:98%
存储:Store at -20°C

Background:

GSK3 inhibitor XV is a racemic mixture of (R)-GSK3 inhibitor XV and (S)-GSK3 inhibitor XV. (R)-GSK3 inhibitor XV inhibits glycogen synthase kinase (GSK) 3α and β (IC50s = 0.35 and 0.55 nM, respectively). It selectively inhibits GSK3α and β over a kinase panel including MSK1, RSK1, and TRKA (IC50s = 3,000, 8,000, and 350 nM, respectively), however, it also inhibits PIM-1 with an IC50 value of 35 nM. (R)-GSK3 inhibitor XV (1 μM) disrupts development of the anterior and posterior termini in zebrafish embryos. (S)-GSK3 inhibitor XV is less potent than the (R)-enantiomer, is selective for PIM-1 over GSK3 (IC50s = 3, 80, and 90 nM for PIM-1, GSK3α, and GSK3β, respectively), and has no effect on zebrafish embryonic development.