| CAS NO: | 182507-22-8 |
| 包装: | 1mg |
| 规格: | 98% |
| 市场价: | 4422元 |
| 分子量: | 649.7 |
Background:
Raloxifene 4’-glucuronide is a metabolite of the selective estrogen receptor modulator raloxifene . It is formed from raloxifene via the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1, UGT1A8, and UGT1A10. It binds to the estrogen receptor with an IC50 value of 370 nM. Raloxifene 4’-glucuronide inhibits the voltage-gated potassium channel Kv4.3 by 6.2 and 20.1% when used at concentrations of 10 and 30 µM, respectively.
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