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JNJ0966
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JNJ0966图片
CAS NO:315705-75-0
规格:98%
分子量:360.45
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
JNJ0966是一种高选择性MMP-9酶原抑制剂,其IC50值为440nM。
CAS:315705-75-0
分子式:C16H16N4O2S2
分子量:360.45
纯度:98%
存储:Store at -20°C

Background:

JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM.


JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM. The activations of proMMP-1, proMMP-2, and proMMP-3 are not significantly different in the presence or absence of 10 μM JNJ0966, whereas proMMP-9 activation by trypsin is significantly attenuated by JNJ0966. The addition of JNJ0966 to the reaction results in a significant reduction in fully processed MMP-9 and an apparent accumulation of the intermediate species[1].


The exposures of JNJ0966 are dose-dependent, with plasma and brain concentrations for the 10-mg/kg dose of 77.5±31.1 ng/mL (215 nM) and 481.6±162.5 ng/g (