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DHMEQ racemate(rel-DHMEQ)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DHMEQ racemate(rel-DHMEQ)图片
CAS NO:287194-38-1
规格:98%
分子量:261.23
包装与价格:
包装价格(元)
2mg电议
5mg电议

产品介绍
DHMEQracemate是一种NF-κB抑制剂。DHMEQracemate抑制NF-κB的活性低于(-)-DHMEQ。
CAS:287194-38-1
分子式:C13H11NO5
分子量:261.23
纯度:98%
存储:Store at -20°C

Background:

DHMEQ racemate is a NF-κB inhibitor. DHMEQ racemate is less active than (-)-DHMEQ.


DHMEQ racemate (DHM3EQ) and (-)-DHMEQ (DHM2EQ) inhibits TNF-a-induced NF-kB activation. (-)-DHMEQ is more potent and less toxic than DHMEQ racemate[1].


The antiarthritic effects of (-)-DHMEQ (DHM2EQ) and DHMEQ racemate (DHM3EQ) are examined on type-II collagen-induced arthritis in DBA1/J mice. This animal model is widely used for evaluation of antirheumatic drugs because of its pathological similarities to human rheumatoid arthritis. The arthritis is elicited and scored. (-)-DHMEQ markedly inhibits type-II-collagen-induced arthritis in mice, whereas DHMEQ racemate tends to only slightly inhibit it[1].


[1]. Matsumoto N, et al. Synthesis of NF-kappaB activation inhibitors derived from epoxyquinomicin C. Bioorg Med Chem Lett. 2000 May 1;10(9):865-9.