ATP-polyamine-biotin 是一种细胞渗透性的有效激酶底物, 与其他已知的ATP类似物具有相似的转换和动力学特性, 细胞毒性EC50值为19 ± 1 nM。
CAS：1800401-93-7
分子式：C32H58N11O14P3S
分子量：945.85
纯度：98%
存储：Store at -20°C

Background:

ATP-polyamine-biotin is a cell-permeable, efficient kinase cosubstrate with conversions and kinetics similar to those of other known ATP analogues. APB shows a cytotoxicity EC50 value of 19 ± 1 mM.ATP-polyamine-biotin is shown to promote biotin labeling of kinase substrates in live cells and has future applications in phosphoprotein purification and analysis. APB is cell-permeable and nontoxic at low mM concentrations, with cell penetration and labeling dependent on the polyamine linker.

[1]. Fouda AE, Pflum MK. A Cell-Permeable ATP Analogue for Kinase-Catalyzed Biotinylation. Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9618-21.