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Curzerene
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Curzerene图片
CAS NO:17910-09-7
规格:98%
分子量:216.32
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Curzerene 是倍半萜,从 Curculigo orchioides Gaertn 的根茎中分离出来的,具有抗癌活性。 Curzerene 抑制谷胱甘肽 S-转移酶 A1 (GSTA1) mRNA 和蛋白表达。Curzerene 诱导细胞凋亡(apoptosis)。
CAS:17910-09-7
分子式:C15H20O
分子量:216.32
纯度:98%
存储:Store at -20°C

Background:

Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. Curzerene induces cell apoptosis[1]. GSTA1[1]


Curzerene (0-100 µM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 µM, and 47.01 µM, respectively[1].Curzerene (0-100 µM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells[1].Curzerene(0-100 µM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose[1].Curzerene (6.25-100 µM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells[1].Curzerene (6.25-100 µM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells[1]. Cell Viability Assay[1] Cell Line: SPC-A1 cells



[1]. Wang Y, et al. Cytotoxic and Antitumor Effects of Curzerene from Curcuma longa. Planta Med. 2017 Jan;83(1-02):23-29.