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Roscovitine(Seliciclib,CYC202)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Roscovitine(Seliciclib,CYC202)图片
CAS NO:186692-46-6
规格:98%
分子量:354.45
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
100mg电议

产品介绍
CDK inhibitor,potent and selective
CAS:186692-46-6
分子式:C19H26N6O
分子量:354.45
纯度:98%
存储:Store at -20°C

Background:

Roscovitine, also known as seliciclib or CYC202, is a selective cyclin-dependent kinases (cdk), which are essential cell cycle regulators frequently involved in the deregulation of human tumors, inhibitor that potently inhibits cdc2 (cdc2/cyclin B), cdk2 (cdk2/cyclin A and cdk2/cyclin E) and cdk5 (cdk5/p35) with half maximal inhibition concentration IC50 of 0.65 μM, 0.7 μM, 0.7 μM and 0.16 μM respectively [1].


Roscovitine has been found to inhibit cellular prophase/metaphase transition at micromolar concentrations, where it inhibits progesterone-induced oocyte maturation of Xenopus oocytes and arrests starfish oocytes and sea urchin embryos in late prophase [1].


Additionally, roscovitine is capable of inhibiting extracelluar regulated kinases, erk1 and erk2, with IC50 of 34 μM and 14 μM respectively [1].


参考文献:
[1] Meijer L, Borgne A, Mulner O, Chong JP, Blow JJ, Inagaki N, Inagaki M, Delcros JG, Moulinoux JP. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem. 1997 Jan 15;243(1-2):527-36.