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WZ811
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WZ811图片
CAS NO:55778-02-4
规格:98%
分子量:290.36
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议
500mg电议
1g电议

产品介绍
Competitive CXCR4 antagonist,highly potent
CAS:55778-02-4
分子式:C18H18N4
分子量:290.36
纯度:98%
存储:Store at -20°C

Background:

WZ811 is a small molecule antagonist of CXC chemokine receptor 4 (CXCR4) [1].


WZ811 is synthesized with two aromatic amine moieties. It is found to effectively inhibit TN14003 binding to CXCR4 with EC50 value of 0.3nM at first. And then WZ811 is found to have ability in counteracting SDF-1 function and blocking CXCR4/SDF-1-mediated signaling. In the cAMP assay, WZ811 reduces the effect on cAMP caused by 150ng/ml SDF-1 significantly. It also blocks the SDF-1 induced Matrigel invasion with EC50 value of 5.2nM. Since CXCR4 is involved in the pathogeneses of a wide range of infectious, inflammatory and other diseases, WZ811 is developed for the treatment of various CXCR4-related diseases. It is reported to have weak anti-HIV activity in cell culture [1, 2].


参考文献:
[1] Zhan W, Liang Z, Zhu A, et al. Discovery of small molecule CXCR4 antagonists. Journal of medicinal chemistry, 2007, 50(23): 5655-5664.
[2] Choi W T, Duggineni S, Xu Y, et al. Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4). Journal of medicinal chemistry, 2011, 55(3): 977-994.