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Dofetilide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dofetilide图片
CAS NO:115256-11-6
包装:10mg
规格:98%
市场价:554元
分子量:441.56

产品介绍
Potassium channel inhibitor
CAS:115256-11-6
分子式:C19H27N3O5S2
分子量:441.56
纯度:98%
存储:Store at -20°C

Background:

Dofetilide(Tikosyn) is a class III antiarrhythmic agent.Target: Potassium ChannelIn patients with congestive heart failure and reduced left ventricular function, dofetilide was effective in converting atrial fibrillation, preventing its recurrence, and reducing the risk of hospitalization for worsening heart failure. Dofetilide had no effect on mortality [1]. dofetilide preferentially blocks open (or activated) channels and that the fast inactivation may competitively slow the binding kinetics. Dofetilide acts as a slow-onset/slow-offset open channel blocker of this current at nanomolar concentrations [2].


参考文献:
[1]. Maisch, B., et al., [Pregnancy and cardiomyopathies]. Herz, 2003. 28(3): p. 196-208.
[2]. Snyders, D.J. and A. Chaudhary, High affinity open channel block by dofetilide of HERG expressed in a human cell line. Mol Pharmacol, 1996. 49(6): p. 949-55.