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1H-1-ethyl Candesartan Cilexetil
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
1H-1-ethyl Candesartan Cilexetil图片
CAS NO:914613-35-7
规格:98%
分子量:638.7
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
selective angiotensin II type 1 receptor (AT1) antagonist
CAS:914613-35-7
分子式:C35H38N6O6
分子量:638.7
纯度:98%
存储:Store at -20°C

Background:

1H-1-ethyl Candesartan Cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist.


Angiotensin II is a peptide that is mainly generated by the angiotensin converting enzyme and chymase, which plays a vital role in regulating blood pressure and sodium homeostasis via specific receptors including AT1[1]. AT1, localized in the kidney, heart, brain, adrenal gland, adipocytes, vascular smooth muscle cells, platelets, and placenta, is a major component of the renin-angiotensin system. Furthermore, AT1 mediates the classical biological actions of angiotensin II. Also, AT1 has seven helical transmembrane domains, which is the characteristic of the superfamily of G-protein-coupled receptors. Carboxyl-terminal region structure of AT1 plays important roles in receptor internalization, desensitization and phosphorylation [2].


In vitro: Up to now, in vitro study of 1H-1-ethyl candesartan cilexetil is still in the development stage.


In vivo: Up to now, in vivo study of 1H-1-ethyl candesartan cilexetil is still in the development stage.


参考文献:
[1].  Otsuka, M. Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist. Thorax. 2004; 59(1): 31-38.
[2].  GUO, D., SUN, Y., HAMET, P., & INAGAMI, T. The angiotensin II type 1 receptor and receptor-associated proteins. Cell Research. 2001; 11(3): 165-180.