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Dapagliflozin-3-O-β-D-Glucuronide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dapagliflozin-3-O-β-D-Glucuronide图片
CAS NO:1351438-75-9
规格:98%
分子量:585
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍

Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin.
CAS:1351438-75-9
分子式:C27H33ClO12
分子量:585
纯度:98%
存储:Store at -20°C

Background:

Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin . Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.[1]  Dapagliflozin is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A9 to dapagliflozin-3-O-β-D-glucuronide, which is 2,600-fold less potent than the parent compound with regard to SGLT2 inhibition.[2]

参考文献:

[1]. Chao, E.C., and Henry, R.R. SGLT2 inhibition - A novel strategy for diabetes treatment. Nature Reviews.Drug Discovery 9(7), 551-559 (2010).
[2]. van der Walt, J.-S., Hong, Y., Zhang, L., et al. A nonlinear mixed effects pharmacokinetic model for dapagliflozin and dapagliflozin 3-O-glucuronide in renal or hepatic impairment. CPT Pharmacometrics Syst. Pharmacol. 2(e42), 1-9 (2013)