CAS NO: | 1351438-75-9 |
规格: | 98% |
分子量: | 585 |
包装 | 价格(元) |
500ug | 电议 |
1mg | 电议 |
Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin.
CAS:1351438-75-9
分子式:C27H33ClO12
分子量:585
纯度:98%
存储:Store at -20°C
Background:
Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin . Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.[1] Dapagliflozin is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A9 to dapagliflozin-3-O-β-D-glucuronide, which is 2,600-fold less potent than the parent compound with regard to SGLT2 inhibition.[2]参考文献:
[1]. Chao, E.C., and Henry, R.R. SGLT2 inhibition - A novel strategy for diabetes treatment. Nature Reviews.Drug Discovery 9(7), 551-559 (2010).