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Z-AEVD-FMK
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Z-AEVD-FMK图片
CAS NO:1135688-47-9
规格:98%
分子量:610.6
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.
CAS:1135688-47-9
分子式:C28H39FN4O10
分子量:610.6
纯度:98%
存储:Store at -20°C

Background:

Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 &#181M, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.[2]


Reference:
[1]. Park, S.J., Wu, C.H., Gordon, J.D., et al. Taxol induces caspase-10-dependent apoptosis. The Journal of Biological Chemisty 279(49), 51057-51067 (2004).
[2]. Milhas, D., Cuvillier, O., Therville, N., et al. Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis. The Journal of Biological Chemisty 280(20), 19836-19842 (2005).