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[Leu5]-Enkephalin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
[Leu5]-Enkephalin图片
CAS NO:58822-25-6
包装:25mg
规格:98%
市场价:964元
分子量:555.63

产品介绍
Endogenous opioid agonist peptide
CAS:58822-25-6
分子式:C28H37N5O7
分子量:555.63
纯度:98%
存储:Store at -20°C

Background:

[Leu5]-Enkephalin is a pentapeptides with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.


Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. Ki=18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas[1].Leucine-enkephalin is a pentapeptides with morphine like properties, naturally present in mammalian brain[2].


参考文献:
[1]. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.
[2]. Meunier JC, et al. Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 1977 May 15;77(2):209-13.