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Minaprine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:25905-77-5
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

Minaprine is an antidepressant that was used the treatment of depression. A study found that it acts as a reversible inhibitor of MAO-A (RIMA) in rats. In a study it has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates. References: Edwards JG, Dinan TG, Waller DG, Greentree SG. Double-blind comparative study of the antidepressant, unwanted and cardiac effects of minaprine and amitriptyline. Br J Clin Pharmacol. 1996 Oct;42(4):491-8. PubMed PMID: 8904622; PubMed Central PMCID: PMC2042690. 2: Jouglard J, Perringue C, Goujard J, Servetti A, David JM. [Evaluation by poison control centers of minaprine from the modification of tablet dosages]. Therapie. 1996 Sep-Oct;51(5):582-5. French. PubMed PMID: 9138401. 3: Allain H, Belliard S, Lieury A, Menard G, Patat A, Le Coz F, Gandon JM. [Randomized double-blind comparative study of minaprine (200mg/j) and of placebo on memory loss]. Therapie. 1996 Mar-Apr;51(2):155-62. French. PubMed PMID: 8763050. 4: Cabib S, Zocchi A, Puglisi-Allegra S. A comparison of the behavioral effects of minaprine, amphetamine and stress. Psychopharmacology (Berl). 1995 Sep;121(1):73-80. PubMed PMID: 8539343. 5: Piao Y, Mineshita S, Kuroiwa T, Koike Y. Prevention by minaprine of ischemic neuronal damage and memory impairment in Mongolian gerbils. Nihon Shinkei Seishin Yakurigaku Zasshi. 1995 Apr;15(2):157-63. PubMed PMID: 7796320. 6: Salzmann E, Robin JL. Multicentric double-blind study comparing efficacy and safety of minaprine and imipramine in dysthymic disorders. Neuropsychobiology. 1995;31(2):68-75. PubMed PMID: 7760988. 7: Sansone M, Battaglia M, Vetulani J. Minaprine, but not oxiracetam, prevents desipramine-induced impairment of avoidance learning in mice. Pol J Pharmacol. 1995 Jan-Feb;47(1):69-73. PubMed PMID: 7550552. 8: Imperato A, Obinu MC, Cabib S, Cestari V, Puglisi-Allegra S. Effects of subchronic minaprine on dopamine release in the ventral striatum and on immobility in the forced swimming test. Neurosci Lett. 1994 Jan 17;166(1):69-72. PubMed PMID: 8190361. 9: Chaki S, Muramatsu M, Otomo S. Involvement of protein kinase C activation in regulation of acetylcholine release from rat hippocampal slices by minaprine. Neurochem Int. 1994 Jan;24(1):37-41. PubMed PMID: 8130734. 10: Puglisi-Allegra S, Cabib S, Cestari V, Castellano C. Post-training minaprine enhances memory storage in mice: involvement of D1 and D2 dopamine receptors. Psychopharmacology (Berl). 1994 Jan;113(3-4):476-80. PubMed PMID: 7862862. 1 Kinirons MT, Jackson SH, Kalra L, Trevit RT, Swift CG. Computerised psychomotor performance testing: a comparative study of the single dose pharmacodynamics of minaprine and amitriptyline in young and elderly subjects. Br J Clin Pharmacol. 1993 Oct;36(4):376-9. PubMed PMID: 12959320; PubMed Central PMCID: PMC1364695. 12: Lorenzini CA, Baldi E, Bucherelli C, Tassoni G. Minaprine facilitates acquisition and retrieval of an active avoidance response in the rat. Pharmacol Biochem Behav. 1993 Jun;45(2):481-5. PubMed PMID: 8327555. 13: Bastion Y, Vial T, Espinouse D, Viala JJ, Coiffier B. [Three cases of acute agranulocytosis: caused by minaprine?]. Presse Med. 1993 Jan 23;22(2):82-3. French. PubMed PMID: 8098526. 14: Kodama K, Shibata S, Ueki S. Protective effect of minaprine against the abnormal changes of 2-deoxyglucose uptake by rat hippocampal slices induced by hypoxia/hypoglycemia. Jpn J Pharmacol. 1992 Sep;60(1):33-8. PubMed PMID: 1361012. 15: Wheatley D. Minaprine in depression. A controlled trial with amitriptyline. Br J Psychiatry. 1992 Jul;16113-5. PubMed PMID: 1638306. 16: Karasawa Y, Araki H, Otomo S. Cholinomimetic activity of minaprine is related to the amelioration of delayed neuronal death in gerbils. Physiol Behav. 1992 Jul;52(1):141-7. PubMed PMID: 1528997. 17: Ambrogi Lorenzini C, Baldi E, Bucherelli C, Tassoni G. Minaprine cancels scopolamine effects on the rat's acquisition of passive avoidance responses in two multitrial paradigms. Pharmacol Biochem Behav. 1992 Apr;41(4):715-8. PubMed PMID: 1594638. 18: Marre F, Fabre G, Lacarelle B, Bourrie M, Catalin J, Berger Y, Rahmani R, Cano JP. Involvement of the cytochrome P-450IID subfamily in minaprine 4-hydroxylation by human hepatic microsomes. Drug Metab Dispos. 1992 Mar-Apr;20(2):316-21. PubMed PMID: 1352227. 19: Davi H, Bonnet JM, Berger Y. Disposition of minaprine in animals and in human extensive and limited debrisoquine hydroxylators. Xenobiotica. 1992 Feb;22(2):171-84. PubMed PMID: 1632106. 20: Montgomery SA, Baldwin DS, Priest RG, Steinert J, Patel A, Herrington RN, Livingston HM. Minaprine and dose response in depression. An investigation of two fixed doses of minaprine compared with imipramine. Pharmacopsychiatry. 1991 Sep;24(5):168-74. PubMed PMID: 1775522.

纯度:≥98%

CAS:25905-77-5