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D159687
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
D159687图片
CAS NO:1155877-97-6
规格:98%
分子量:366.84
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
D159687是一种选择性PDE4D抑制剂。
CAS:1155877-97-6
分子式:C21H19ClN2O2
分子量:366.84
纯度:98%
存储:Store at -20°C

Background:

D159687 is a selective PDE4D inhibitor[1]. PDE4D[1]


D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment[1].D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM[1]. Western Blot Analysis[1] Cell Line: HT-22 (mouse hippocampal cell line)


D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques[2]. Animal Model: Female Cynomolgus macaques (4-6 year old) [2]


[1]. Zhang C, et al. Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System. Sci Rep. 2017 Jan 5;7:40115.