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Mesoridazine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mesoridazine图片
CAS NO:5588-33-0
规格:98%
分子量:386.57
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍

Dopaminergic antagonist
CAS:5588-33-0
分子式: C21H26N2OS2
分子量:386.57
纯度:98%
存储:Store at -20°C
库存:现货


Background:

Mesoridazine is an active metabolite of the typical antipsychotic thioridazine.[1],[2] It is formed via sulfoxidation of thioridazine by the cytochrome P450 (CYP) isoform CYP2D6 in human liver microsomes.[3] It binds to histamine H1, dopamine D2, muscarinic acetylcholine, and α1- and α2-adrenergic receptors (Kds = 1.8, 19, 69, 2, and 1,600 nM, respectively).[2] Mesoridazine (10, 30, and 45 mg/kg, i.p.) prevents mescaline-induced hyperactivity in mice.[4]

参考文献:
[1]. von Bahr, C., Movin, G., Nordin, C., et al. Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype. Clin. Pharmacol. Ther. 49(3), 234-240 (1991).
[2]. Richelson, E., and Nelson, A. Antagonism by neuroleptics of neurotransmitter receptors of normal human brain in vitro. Eur. J. Pharmacol. 103(3-4), 197-204 (1984).
[3]. Wójcikowski, J., Maurel, P., and Daniel, W.A. Characterization of human cytochrome P450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine. Drug Metab. Dispos. 34(3), 471-476 (2006).
[4]. Shah, N.S. Influence of psychotropic drugs and β-diethylaminoethyl-diphenylpropylacetate (SKF 525-A) on mescaline-induced behavior and on tissue levels of mescaline in mice. Biochem. Pharmacol. 25(5), 591-597 (1976).