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TA 01
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TA 01图片
CAS NO:1784751-18-3
规格:98%
分子量:351.32
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
CK1ε, CK1δ,and p38α inhibitor
CAS:1784751-18-3
分子式:C20H12F3N3
分子量:351.32
纯度:98%
存储:Store at -20°C

Background:

TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.
TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively. TA-01 (5 μM) is not cytotoxic, completely inhibits cardiogenesis, but induces cardiogenesis at lower concentration[1].
Reference:
[1]. Laco F, et al. Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J Mol Cell Cardiol. 2015 Mar;80:56-70.