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Beclabuvir(BMS-791325)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Beclabuvir(BMS-791325)图片
CAS NO:958002-33-0
规格:98%
分子量:659.84
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Beclabuvir是HCVNS5BRNA-依赖性RNA聚合酶抑制剂,也可抑制HCV基因型1,2,4,5表达的NS5B蛋白活性,IC50值均<28nM。
CAS:958002-33-0
分子式:C36H45N5O5S
分子量:659.84
纯度:98%
存储:Store at -20°C

Background:

Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of< 28 nM.


Beclabuvir demonstrates additive or synergistic antiviral activity with pegIFN/RBV and in 2- or 3-drug combinations with a range of DAAs, such as HCV NS3 protease inhibitors, NS5A inhibitors’ and/or nucleoside NS5B inhibitors[2].


The combination of beclabuvir with asunaprevir and daclatasvir achieves very high rates of viral eradication (about 90%) in patients infected with HCV genotype 1, which is the most common genotype worldwide[1].


[1]. Gentile I, et al. Beclabuvir for the treatment of hepatitis C. Expert Opin Investig Drugs. 2015;24(8):1111-21. [2]. Tatum H, et al. A randomized, placebo-controlled study of the NS5B inhibitor beclabuvir with peginterferon/ribavirin for HCV genotype 1. J Viral Hepat. 2015 Aug;22(8):658-64.