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D77
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
D77图片
CAS NO:497836-10-9
规格:98%
分子量:596.45
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
D77是一种抗HIV-1抑制剂,靶向作用于整合酶与细胞LEDGF/p75的相互作用,D77抑制HIV-1(IIIB)复制,作用于MT-4细胞时,EC50值为23.8μg/ml(C8166细胞时,EC50值为5.03μg/ml)。
CAS:497836-10-9
分子式:C28H22BrNO7S
分子量:596.45
纯度:98%
存储:Store at -20°C

Background:

D77 is anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. D77 inhibits HIV-1(IIIB) replication by EC50 value of 23.8 μg/ml in MT-4 cell (5.03 μg/ml for C8166 cells).IC50 value: 23.8 μg/ml (EC50, in MT-4 cell ), 5.03 μg/ml (EC50, in C8166 cell)Target: HIV-1in vitro: D77 exhibits a highly specific binding affinity to HIV-1 integrase catalytic core domain.D77 induces a dramatic concentration-dependent decrease of α-galactosidase activity compared to the D77-untreated cells. D77 reveals a significant inhibition activity against the interaction of IN with IBD.




[1]. Du L, et al. D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. Biochem Biophys Res Commun. 2008 Oct 10;375(1):139-144.