Fotemustine是一种DNA烷化剂(DNAalkylator)，具有抗肿瘤作用。
CAS：92118-27-9
分子式：C9H19ClN3O5P
分子量：315.69
纯度：98%
存储：Store at -20°C

Background:

Fotemustine is a DNA-alkylating agent, with antitumor activity.

Fotemustine is a DNA-alkylating agent. Fotemustine (800 μM) decreases GSH and intracellular GSSG levels but increases the extracellular GSSG-levels rapidly in isolated rat hepatocytes[1]. Fotemustine shows inhibitory effect on several tumor cell lines, with IC50s ranging form 0.05 to 0.18 mM[2].

[1]. Brakenhoff JP, et al. Molecular mechanisms of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions. Carcinogenesis. 1996 Apr;17(4):715-24. [2]. Merlin JL, et al. Enhancement of fotemustine (Muphoran) cytotoxicity by amifostine in malignant melanoma cell lines. Anticancer Drugs. 2002 Feb;13(2):141-7.