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Cholic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cholic acid图片
CAS NO:81-25-4
包装:20mg
规格:98%
市场价:270元
分子量:408.58

产品介绍
ApplicationNon-denaturing ionic detergent used for extraction of membrane proteins. ActionsBile AcidPackaging1 kg in poly bottle25,100,500 g in poly bottle
CAS:81-25-4
分子式:C24H40O5
分子量:408.58
纯度:98%
存储:Store at -20°C

Background:

Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.


Cholic acid competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway[1].


Cholic acid feeding leads to increased CYP2D6 expression in CYP2D6-humanized mice. As a cholestasis model, Tg-CYP2D6 mice are fed a Cholic acid (CA)-supplemented diet for over 1 week. The treatment is known to increase bile acid pool size by 2-fold and to replace