Peptide inhibitor of GTPase dynamin
CAS：251634-21-6
分子式：C47H80N18O14
分子量：1121.26
纯度：98%
存储：Store at -20°C

Background:

Dynamin Inhibitory Peptide is a peptide (Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro) inhibitor of the GTPase dynamin.

Dynamin is a 100-kDa large GTPase that functions to tabulate membranes and liberate nascent vesicles from the Golgi apparatus and plasma membrane. Dynamin also plays a role in many processes including division of organelles,cytokinesis and microbial pathogen resistance.

Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABA_Areceptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABA_Areceptors.

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