您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > MX69
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
MX69
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MX69图片
CAS NO:1005264-47-0
规格:98%
分子量:474.57
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.
CAS:1005264-47-0
分子式:C27H26N2O4S
分子量:474.57
纯度:98%
存储:Store at -20°C

Background:

MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.


MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro[1].


MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo[1].


参考文献:
[1]. Gu L, et al. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636