HCH6-1 是甲酰肽受体1 (FPR1) 的竞争性拮抗剂，治疗中性粒细胞炎性疾病的新兴治疗靶标。HCH6-1 是一种 FPR1 抑制剂，对急性肺损伤 (ALI) 具有保护作用。HCH6-1 抑制由 fMLF (FPR1激动剂) 激活的人嗜中性粒细胞中的超氧阴离子产生，弹性蛋白酶释放和趋化性。
CAS：1435265-06-7
分子式：C28H27N3O4
分子量：469.53
纯度：98%
存储：Store at -20°C

Background:

HCH6-1 is a competitive antagonist of Formyl peptide receptor 1 (FPR1), an emerging therapeutic target for the discovery of drugs to treat neutrophilic inflammatory diseases. HCH6-1 is a selective FPR1 inhibitor and has protective effects against acute lung injury (ALI). HCH6-1 inhibits superoxide anion generation, elastase release, and chemotaxis in human neutrophils activated by fMLF (an FPR1 agonist).

[1]. Yang SC, et al. Dipeptide HCH6-1 inhibits neutrophil activation and protects against acute lung injury by blocking FPR1. Free Radic Biol Med. 2017 May;106:254-269