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Escin IA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Escin IA图片
CAS NO:123748-68-5
包装:20mg
规格:98%
市场价:1719元
分子量:1131.26

产品介绍
Extracted?from?Aesculus chinensis Bge fruit;Store?the?product?in?sealed,?cool?and?dry?condition
CAS:123748-68-5
分子式:C55H86O24
分子量:1131.26
纯度:98%
存储:Store at -20°C

Background:

Escin IA is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression[1][2].


参考文献:
[1]. Yang XW, et al. Anti-HIV-1 protease triterpenoid saponins from the seeds of Aesculus chinensis. J Nat Prod. 1999 Nov;62(11):1510-3.
[2]. Wang Y, et al. Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression. Oncotarget. 2016 Apr 26;7(17):23684-99.