Initiates neurodegeneration in Alzheimer disease
CAS：152286-31-2
分子式：C71H99N17O16
分子量：1446.67
纯度：98%
存储：Store at -20°C

Background:

The amyloid β-peptide (Aβ) has a central role in initiating neurodegeneration in Alzheimer disease (AD)¹. It is widely believed to be an incidental catabolic byproduct of the amyloid β protein precursor (APP) with no normal physiological function.²

Aβ has been shown to be a ligand for a number of different receptors and other molecules^3-5.? It is transported between tissues and across the blood brain barrierby complex trafficking pathways⁶.? Aβ is modulated in response to a variety of environmental stressors and is able to induce pro-inflammatory activities⁷.

Soluble amyloid β-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17.

参考文献:
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3. Le Y, Gong W, Tiffany HL, Tumanov A, Nedospasov S, et al. (2001) Amyloid (b)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1.J Neurosci 21: RC123.
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5. Maezawa I, Jin LW, Woltjer RL, Maeda N, Martin GM, et al. (2004) Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity. J Neurochem 91: 1312–1321.
6. Tanzi RE, Moir RD, Wagner SL (2004) Clearance of Alzheimer’s Ab peptide: the many roads to perdition. Neuron 43: 605–608.
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