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Vandetanib(ZD6474)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vandetanib(ZD6474)图片
CAS NO:443913-73-3
规格:98%
分子量:475.35
包装与价格:
包装价格(元)
25mg电议
100mg电议

产品介绍
VEGFR2/EGFR antagonist
CAS:443913-73-3
分子式:C22H24BrFN4O2
分子量:475.35
纯度:98%
存储:Store at -20°C

Background:

ZD6474 is a dual inhibitor of VEGFR-2 and EGFR with IC50 values of 40 nM and 500 nM, respectively [1].


ZD6474 showed potent inhibition activities against recombinant VEGFR-2 and EGFR in the in vitro assays. The inhibition of VEGFR-2 was 2.7-fold more potent than that of VEGFR-3 (Flt-4) kinase and 40-fold more potent than that of VEGFR-1. In human umbilical vein endothelial cells, treatment of ZD6474 resulted in significant inhibition of cell proliferation stimulated by VEGF and EGF with IC50 values of 60 and 170 nM, respectively. Through inhibiting the kinase activity of EGFR, ZD6474 can inhibit cell growth of various cancer cell lines, including lung, ovarian, breast and colon cancers. Besides that, ZD6474 administration inhibited tumor growth in a dose-dependent manner in many tumor xenograft models.


参考文献:
[1] Ryan A J, Wedge S R. ZD6474–a novel inhibitor of VEGFR and EGFR tyrosine kinase activity[J]. British journal of cancer, 2005, 92: S6-S13.