Procyanidin C1 is a polyphenol flavonoid trimer of (-)-epicatechin that has HIV-related and antioxidant activities.
CAS：37064-30-5
分子式：C45H38O18
分子量：866.8
纯度：98%
存储：Store at -20°C

Background:

Procyanidin C1 is a polyphenol flavonoid trimer of (-)-epicatechin that has HIV-related and antioxidant activities. It activates latent HIV-1 provirus in JLR2 cells when used at concentrations ranging from 12.5 to 50 µM and increases NF-κB-dependent transcriptional activity in Jurkat T cells. Procyanidin C1 also scavenges 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 3.2 µg/ml) and inhibits the activity of α-glucosidase (IC50 = 3.8 µg/ml) and 15-lipoxygenase (15-LO; IC50 = 57.6 µg/ml). Procyanidin C1 (10 µg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells.