Description: BGP-15 HCl is a potent and novel PARP inhibitor that can protect against heart failure and atrial fibrillation in mice. BGP-15 (200 μM) prevents the imatinib mesylate-induced oxidative damages, attenuates the depletion of high-energy phosphates, alters the signaling effect of imatinib mesylate by preventing p38 MAP kinase and JNK activation, and induced the phosphorylation of Akt and GSK-3beta. In-vivo study indicated that BGP-15 improved cardiac function and reduced arrhythmic episodes in two HF and AF mouse models. In these models, BGP-15 was associated with increased phosphorylation of IGF1R.

References: Am J Pathol. 2016;186:3246-3260; Sci Transl Med. 2016;8(350):350ra103; Nat Commun. 2014;5:5705.

Related CAS #: 66611-37-8 (HCl) 66611-38-9 (free base)

纯度：≥98%

CAS：66611-37-8