potent blocker of the slow component of delayed rectifier potassium current (IKs)
CAS：878489-28-2
分子式：C21H29ClN2O4S
分子量：440.98
纯度：98%
存储：Store at -20°C

Background:

JNJ 303 is a potent blocker of the slow component of delayed rectifier potassium current (IKs) [1] with an IC50 value of 0.064 μM [2].

Accompanied by the transient outward current (Ito), IKs channel is a main potassium channel that affects cardiac repolarisation and thus the length of the QT interval [2].

Dofetilide accompanied by JNJ 303 resulted in an additional 80% field potential prolongation. Sotalol administration with JNJ 303 in hPSC-CM resulted in an additional maximum prolongation of field potential (FP) duration of