MK-142 dimethanesulfonate is a bioactive agent with antiarrhythmic properties. The relatively high content of MK-142 in the myocardium as compared with its content in the skeletal muscles indicates a high affinity of the examined substance to the heart muscle. MK-142 is excreted via kidneys, alimentary tract and respiratory ways. References: Noyszewska-Skibińska I, Nowicka A, Ernest K, Nowicka J. Biochemical, morphochemical and pharmacodynamic evaluation of accumulation of ethylenediamine derivatives (ROM-203, MK-142) in some rat tissues. Mater Med Pol. 1977 Jul-Sep;9(3):216-24. PubMed PMID: 926836. 2: Ernest K. Pharmacology of new ethylenediamine derivatives (ROM-126, ROM-131, MK-142) with antiarrhythmic action. Part II. Antiarrhythmic properties, the influence on heart and some hemodynamic parameters. Pol J Pharmacol Pharm. 1975 Jul-Aug;27(4):381-98. PubMed PMID: 1166019. 3: Ernest K. The pharmacology of new ethylenediamine derivatives (ROM-126, ROM-131, MK-142) with antiarrhythmic action. Part I. General pharmacological properties. Pol J Pharmacol Pharm. 1975 Jul-Aug;27(4):363-79. PubMed PMID: 241067. 4: Nowicka A, Prussak T, Szukalski B. Metabolism of some ethylenediamine derivatives with antiarrhythmic properties. I. Absorption, distribution in tissues and excretion of 14-C labelled N, N'-bis-[3-(p-methoxyphenoxy)-2-hydroxypropyl]-ethylenediamine dimethanesulphonate (MK-142) in rats. Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):113-20. PubMed PMID: 168561.

纯度：≥98%

CAS：42794-63-8