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K02288
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
K02288图片
CAS NO:1431985-92-0
规格:98%
分子量:352.38
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
ALK inhibitor
CAS:1431985-92-0
分子式:C20H20N2O4
分子量:352.38
纯度:98%
存储:Store at -20°C

Background:

K02288 is a highly selective inhibitor of ALK2 with IC50 value of 1.1nM [1].


K02288 is a 2-aminopyridine inhibitor of ALK2. It shows high selectivity for the homologous kinases ALK1-6 and ActRIIA. K02288 shows potency against the type I BMP receptors ALK1, ALK2 (IC50s range from 1–2nM), ALK3 and ALK6 (IC50s of 5–34nM), ALK4 (IC50 of 302nM) and ALK5 (IC50 of 321nM). K02288 has a favorable kinome-wide selectivity. In a panel of 200 human kinases, it shows more than 50% inhibition against only ABL and ARG at 0.1μM and only a further 6 kinases at 1μM [1].


K02288 also affects ALK2 related BMP signaling. In C2C12 cells, it reduces the phosphorylation of Smad dose-dependently when using BMP4 or BMP6 as ligands. Furthermore, K02288 induces a dorsalized phenotype in Tg(BRE:mRFP) transgenic zebrafish embryos [1].


参考文献:
[1] Sanvitale CE, Kerr G, Chaikuad A, Ramel MC, Mohedas AH, Reichert S, Wang Y, Triffitt JT, Cuny GD, Yu PB, Hill CS, Bullock AN. A new class of small molecule inhibitor of BMP signaling. PLoS One. 2013 Apr 30;8(4):e62721.